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1

Effect of Antimalarial Drugs on Plasmodium falciparum Gametocytes

Peatey, Christopher L., Skinner‐Adams, Tina S., Dixon, Matthew W. A., McCarthy, James S., Gardiner, Donald L., Trenholme, Katharine R.

Journal:

The Journal of Infectious Diseases

Year:

2009

Language:

english

File:

PDF, 421 KB

english, 2009

2

The effect of a fibroblast feeder layer, L-cysteine and 2-mercaptoethanol on the growth of Plasmodium falciparum in vitro

Katharine R. Trenholme, Fiona A. McMonagle, R.Stephen Phillips

Journal:

Transactions of the Royal Society of Tropical Medicine and Hygiene

Year:

1990

Language:

english

File:

PDF, 427 KB

english, 1990

3

A real-time, quantitative PCR method using hydrolysis probes for the monitoring ofPlasmodium falciparumload in experimentally infected human volunteers

Rebecca J Rockett, Sarah J Tozer, Chris Peatey, Seweryn Bialasiewicz, David M Whiley, Michael D Nissen, Katharine Trenholme, James S Mc Carthy, Theo P Sloots

Journal:

Malaria Journal

Year:

2011

Language:

english

File:

PDF, 237 KB

english, 2011

4

An improved method for undertaking limiting dilution assays forin vitrocloning ofPlasmodium falciparumparasites

Alice S Butterworth, Alan J Robertson, Mei-Fong Ho, Michelle L Gatton, James S McCarthy, Katharine R Trenholme

Journal:

Malaria Journal

Year:

2011

Language:

english

File:

PDF, 249 KB

english, 2011

5

CLAG

DonaldL. Gardiner, Tobias Spielmann, MatthewW.A. Dixon, PaulaL. Hawthorne, MariaR. Ortega, KarenL. Anderson, TinaS. Skinner-Adams, DavidJ. Kemp, KatharineR. Trenholme

Journal:

Parasitology Research

Year:

2004

Language:

english

File:

PDF, 1.96 MB

english, 2004

6

Invasion of Rh Null Cells byPlasmodium falciparumidentifies a new invasion pathway

Wendy Y. Chung, Donald L. Gardiner, Catharine Hyland, Katharine R. Trenholme

Journal:

Parasitology Research

Year:

2008

Language:

english

File:

PDF, 105 KB

english, 2008

7

REX1 and Pf62: are they one and the same?

Donald L. Gardiner, Ben J. Woodcroft, Matthew W. A. Dixon, Stuart A. Ralph, Katharine R. Trenholme

Journal:

Parasitology Research

Year:

2009

Language:

english

File:

PDF, 150 KB

english, 2009

8

Organization of ETRAMPs and EXP-1 at the parasite–host cell interface of malaria parasites

Tobias Spielmann, Donald L. Gardiner, Hans-Peter Beck, Katharine R. Trenholme, David J. Kemp

Journal:

Molecular Microbiology

Year:

2006

Language:

english

File:

PDF, 386 KB

english, 2006

9

Targeted mutagenesis of the ring-exported protein-1 of Plasmodium falciparum disrupts the architecture of Maurer's cleft organelles

Eric Hanssen, Paula Hawthorne, Matthew W. A. Dixon, Katharine R. Trenholme, Paul J. McMillan, Tobias Spielmann, Donald L. Gardiner, Leann Tilley

Journal:

Molecular Microbiology

Year:

2008

Language:

english

File:

PDF, 923 KB

english, 2008

10

Genetic ablation of a Maurer's cleft protein prevents assembly of the Plasmodium falciparum virulence complex

Matthew W. A. Dixon, Shannon Kenny, Paul J. McMillan, Eric Hanssen, Katharine R. Trenholme, Donald L. Gardiner, Leann Tilley

Journal:

Molecular Microbiology

Year:

2011

Language:

english

File:

PDF, 909 KB

english, 2011

11

Targeting of the Ring Exported Protein 1 to the Maurer’s Clefts is Mediated by a Two-Phase Process

Matthew W. A. Dixon, Paula L. Hawthorne, Tobias Spielmann, Karen L. Anderson, Katharine R. Trenholme, Donald L. Gardiner

Journal:

Year:

2008

Language:

english

File:

PDF, 872 KB

english, 2008

12

Molecular cloning of a myoD-like gene from the parasitic nematode, Trichinella spiralis

Bernadette Connolly, Katharine Trenholme, Deborah F Smith

Journal:

Molecular and Biochemical Parasitology

Year:

1996

Language:

english

File:

PDF, 1.50 MB

english, 1996

13

Reliable transfection of Plasmodium falciparum using non-commercial plasmid mini preparations

Tobias Spielmann, Matthew W.A. Dixon, Maria Hernandez-Valladares, Mandy Hannemann, Katharine R. Trenholme, Donald L. Gardiner

Journal:

International Journal for Parasitology

Year:

2006

Language:

english

File:

PDF, 223 KB

english, 2006

14

A novel Plasmodium falciparum ring stage protein, REX, is located in Maurer’s clefts

Paula L. Hawthorne, Katharine R. Trenholme, Tina S. Skinner-Adams, Tobias Spielmann, Katja Fischer, Matthew W.A. Dixon, Maria R. Ortega, Karen L. Anderson, David J. Kemp, Donald L. Gardiner

Journal:

Molecular and Biochemical Parasitology

Year:

2004

Language:

english

File:

PDF, 230 KB

english, 2004

15

Implication of a Plasmodium falciparum gene in the switch between asexual reproduction and gametocytogenesis

Donald L. Gardiner, Matthew W.A. Dixon, Tobias Spielmann, Tina S. Skinner-Adams, Paula L. Hawthorne, Maria R. Ortega, David J. Kemp, Katharine R. Trenholme

Journal:

Molecular and Biochemical Parasitology

Year:

2005

Language:

english

File:

PDF, 214 KB

english, 2005

16

Enhanced invasion of blood group A1 erythrocytes by Plasmodium falciparum

Wendy Y. Chung, Donald L. Gardiner, Catherine Hyland, Michelle Gatton, David J. Kemp, Katharine R. Trenholme

Journal:

Molecular and Biochemical Parasitology

Year:

2005

Language:

english

File:

PDF, 137 KB

english, 2005

17

The CLAG/RhopH1 locus on chromosome 3 of Plasmodium falciparum: Two genes or two alleles of the same gene?

Wendy Y. Chung, Donald L. Gardiner, Karen A. Anderson, Catharine A. Hyland, David J. Kemp, Katharine R. Trenholme

Journal:

Molecular and Biochemical Parasitology

Year:

2007

Language:

english

File:

PDF, 320 KB

english, 2007

18

A green fluorescent protein-based assay for determining gametocyte production in Plasmodium falciparum

Matthew W.A. Dixon, Christopher L. Peatey, Donald L. Gardiner, Katharine R. Trenholme

Journal:

Molecular and Biochemical Parasitology

Year:

2009

Language:

english

File:

PDF, 331 KB

english, 2009

19

A high-throughput assay for the identification of drugs against late-stage Plasmodium falciparum gametocytes

Christopher L. Peatey, Timothy P. Spicer, Peter S. Hodder, Katharine R. Trenholme, Donald L. Gardiner

Journal:

Molecular and Biochemical Parasitology

Year:

2011

Language:

english

File:

PDF, 446 KB

english, 2011

20

Sex in Plasmodium: a sign of commitment

Matthew W.A. Dixon, Joanne Thompson, Donald L. Gardiner, Katharine R. Trenholme

Journal:

Trends in Parasitology

Year:

2008

Language:

english

File:

PDF, 324 KB

english, 2008

21

Plasmodium falciparum neutral aminopeptidases: new targets for anti-malarials

Tina S. Skinner-Adams, Colin M. Stack, Katharine R. Trenholme, Chris L. Brown, Jolanta Grembecka, Jonathan Lowther, Artur Mucha, Marcin Drag, Pawel Kafarski, Sheena McGowan, James C. Whisstock, Donald

Journal:

Trends in Biochemical Sciences

Year:

2010

Language:

english

File:

PDF, 824 KB

english, 2010

22

The cytoadherence linked asexual gene family of Plasmodium falciparum: are there roles other than cytoadherence?

Deborah C Holt, Donald L Gardiner, Elizabeth A Thomas, Mark Mayo, Peter F Bourke, Colin J Sutherland, Rod Carter, Garry Myers, David J Kemp, Katharine R Trenholme

Journal:

International Journal for Parasitology

Year:

1999

Language:

english

File:

PDF, 128 KB

english, 1999

23

Inhibition of Plasmodium falciparum clag9 gene function by antisense RNA

Donald L Gardiner, Deborah C Holt, Elizabeth A Thomas, David J Kemp, Katharine R Trenholme

Journal:

Molecular and Biochemical Parasitology

Year:

2000

Language:

english

File:

PDF, 304 KB

english, 2000

24

The sequence of clag 9, a subtelomeric gene of Plasmodium falciparum is highly conserved

Jo-Anne Manski-Nankervis, Donald L Gardiner, Paula Hawthorne, Deborah C Holt, Mandy Edwards, David J Kemp, Katharine R Trenholme

Journal:

Molecular and Biochemical Parasitology

Year:

2000

Language:

english

File:

PDF, 59 KB

english, 2000

25

Clags in Plasmodium falciparum and other species of Plasmodium

Deborah C. Holt, Katja Fischer, Marina Tchavtchitch, Danny W. Wilson, Nova E. Hauquitz, Paula L. Hawthorne, Donald L. Gardiner, Katharine R. Trenholme, David J. Kemp

Journal:

Molecular and Biochemical Parasitology

Year:

2001

Language:

english

File:

PDF, 199 KB

english, 2001

26

Diversity in repeat-containing surface proteins of Leishmania major

Paul G McKean, Katharine R. Trenholme, Desikan Rangarajan, Jane K Keen, Deborah F. Smith

Journal:

Molecular and Biochemical Parasitology

Year:

1997

Language:

english

File:

PDF, 497 KB

english, 1997

27

Malaria: A New Gene Family (clag) Involved in Adhesion – Reply

Katharine R Trenholme, Donald L Gardiner, Elizabeth A Thomas, Deborah C Holt, David J Kemp, Alan F Cowman

Journal:

Parasitology Today

Year:

2000

Language:

english

File:

PDF, 113 KB

english, 2000

28

Diagnosing malaria today

Katharine Trenholme

Journal:

Trends in Parasitology

Year:

2002

Language:

english

File:

PDF, 32 KB

english, 2002

29

GATEWAY™ vectors for Plasmodium falciparum transfection

Tina S. Skinner-Adams, Paula L. Hawthorne, Katharine R. Trenholme, Donald L. Gardiner

Journal:

Trends in Parasitology

Year:

2003

Language:

english

File:

PDF, 94 KB

english, 2003

30

Malaria transfection and transfection vectors

Donald L. Gardiner, Tina S. Skinner-Adams, Tobias Spielmann, Katharine R. Trenholme

Journal:

Trends in Parasitology

Year:

2003

Language:

english

File:

PDF, 83 KB

english, 2003

31

Anti-malarial drugs: how effective are they againstPlasmodium falciparumgametocytes?

Christopher L Peatey, Didier Leroy, Donald L Gardiner, Katharine R Trenholme

Journal:

Malaria Journal

Year:

2012

Language:

english

File:

PDF, 198 KB

english, 2012

32

X-ray Crystal Structure and Specificity of the Plasmodium falciparum Malaria Aminopeptidase PfM18AAP

Komagal Kannan Sivaraman, Christine A. Oellig, Kitmun Huynh, Sarah C. Atkinson, Marcin Poreba, Matthew A. Perugini, Katharine R. Trenholme, Donald L. Gardiner, Guy Salvesen, Marcin Drag, John P. Dalto

Journal:

Journal of Molecular Biology

Year:

2012

Language:

english

File:

PDF, 1.48 MB

english, 2012

33

The M17 Leucine Aminopeptidase of the Malaria Parasite Plasmodium falciparum : Importance of Active Site Metal Ions in the Binding of Substrates and Inhibitors

Maric, Selma, Donnelly, Sheila M., Robinson, Mark W., Skinner-Adams, Tina, Trenholme, Katharine R., Gardiner, Donald L., Dalton, John P., Stack, Colin M., Lowther, Jonathan

Journal:

Year:

2009

Language:

english

File:

PDF, 737 KB

english, 2009

34

Heterogeneity of IgG antibody responses to cloned Onchocerca volvulus antigens in microfiladermia positive individuals from Esmeraldas Province, Ecuador

KATHARINE R. TRENHOLME, TIM I. M. TREE, ANDREW J. GILLESPIE, RONALD GUDERIAN, RICK M. MAIZELS, JANETTE E. BRADLEY

Journal:

Parasite Immunology

Year:

1994

Language:

english

File:

PDF, 722 KB

english, 1994

35

Plasmodium falciparum : new molecular targets with potential for antimalarial drug development

Gardiner, Donald L, Skinner-Adams, Tina S, Brown, Christopher L, Andrews, Katherine T, Stack, Colin M, McCarthy, James S, Dalton, John P, Trenholme, Katharine R

Journal:

Expert Review of Anti-infective Therapy

Year:

2009

Language:

english

File:

PDF, 3.73 MB

english, 2009

36

Plasmodium Gametocyte Inhibition Identified from a Natural-Product-Based Fragment Library

Vu, Hoan, Roullier, Catherine, Campitelli, Marc, Trenholme, Katharine R., Gardiner, Donald L., Andrews, Katherine T., Skinner-Adams, Tina, Crowther, Gregory J., Van Voorhis, Wesley C., Quinn, Ronald J

Journal:

ACS Chemical Biology

Year:

2013

Language:

english

File:

PDF, 1.63 MB

english, 2013

37

Identification of Phosphinate Dipeptide Analog Inhibitors Directed against the Plasmodium falciparum M17 Leucine Aminopeptidase as Lead Antimalarial Compounds

Skinner-Adams, Tina S., Lowther, Jonathan, Teuscher, Franka, Stack, Colin M., Grembecka, Jolanta, Mucha, Artur, Kafarski, Pawel, Trenholme, Katharine R., Dalton, John P., Gardiner, Donald L.

Journal:

Journal of Medicinal Chemistry

Year:

2007

Language:

english

File:

PDF, 245 KB

english, 2007

38

Plasmodium falciparum gametocytes: with a view to a kill

BUTTERWORTH, ALICE S., SKINNER-ADAMS, TINA S., GARDINER, DON L., TRENHOLME, KATHARINE R.

Journal:

Year:

2013

Language:

english

File:

PDF, 288 KB

english, 2013

39

Development of cultured Plasmodium falciparum blood-stage malaria cell banks for early phase in vivo clinical trial assessment of anti-malaria drugs and vaccines

Stanisic, Danielle I, Liu, Xue Q, De, Sai Lata, Batzloff, Michael R, Forbes, Tanya, Davis, Christopher B, Sekuloski, Silvana, Chavchich, Marina, Chung, Wendy, Trenholme, Katharine, McCarthy, James S,

Journal:

Malaria Journal

Year:

2015

Language:

english

File:

PDF, 469 KB

english, 2015

40

Aminopeptidases of Malaria Parasites: New Targets for Chemotherapy

R. Trenholme, Katharine, L. Brown, Christopher, S. Skinner-Adams, Tina, Stack, Colin, Lowther, Jonathan, To, Joyce, W. Robinson, Mark, M. Donnelly, Sheila, P. Dalton, John, L. Gardiner, Donald

Journal:

Infectious Disorders - Drug Targets(Formerly Current Drug Targets - Infectious Disorders)

Year:

2010

Language:

english

File:

PDF, 222 KB

english, 2010

41

Dual stage synthesis and crucial role of cytoadherence-linked asexual gene 9 in the surface expression of malaria parasite var proteins

Suchi Goel, Manojkumar Valiyaveettil, Rajeshwara N. Achur, Atul Goyal, Denise Mattei, Ali Salanti, Katharine R. Trenholme, Donald L. Gardiner and D. Channe Gowda

Journal:

Proceedings of the National Academy of Sciences

Year:

2010

Language:

english

File:

PDF, 1.53 MB

english, 2010

42

Linking Murine and Human Plasmodium falciparum Challenge Models in a Translational Path for Antimalarial Drug Development

McCarthy, James S., Marquart, Louise, Sekuloski, Silvana, Trenholme, Katharine, Elliott, Suzanne, Griffin, Paul, Rockett, Rebecca, O'Rourke, Peter, Sloots, Theo, Angulo-Barturen, Iñigo, Ferrer, Santia

Journal:

Antimicrobial Agents and Chemotherapy

Year:

2016

Language:

english

File:

PDF, 865 KB

english, 2016

43

A Plasmodium falciparum S33 proline aminopeptidase is associated with changes in erythrocyte deformability

da Silva, Fabio L., Dixon, Matthew W.A., Stack, Colin M., Teuscher, Franka, Taran, Elena, Jones, Malcolm K., Lovas, Erica, Tilley, Leann, Brown, Christopher L., Trenholme, Katharine R., Dalton, John P

Journal:

Experimental Parasitology

Year:

2016

Language:

english

File:

PDF, 1.57 MB

english, 2016

44

Infectivity of Plasmodium falciparum in malaria-naïve individuals is related to knob expression and cytoadherence of the parasite

Stanisic, Danielle I, Gerrard, John, Fink, James, Griffin, Paul M, Liu, Xue Q, Sundac, Lana, Sekuloski, Silvana, Rodriguez, Ingrid B, Pingnet, Jolien, Yang, Yuedong, Zhou, Yaoqi, Trenholme, Katharine

Journal:

Infection and Immunity

Year:

2016

Language:

english

File:

PDF, 1.93 MB

english, 2016

45

A repeat sequence domain of the ring-exported protein-1 of P lasmodium falciparum controls export machinery architecture and virulence protein trafficking

McHugh, Emma, Batinovic, Steven, Hanssen, Eric, McMillan, Paul J., Kenny, Shannon, Griffin, Michael D. W., Crawford, Simon, Trenholme, Katharine R., Gardiner, Donald L., Dixon, Matthew W. A., Tilley,

Journal:

Molecular Microbiology

Year:

2015

Language:

english

File:

PDF, 1.11 MB

english, 2015

46

Selective permeabilization of the host cell membrane of Plasmodium falciparum -infected red blood cells with streptolysin O and equinatoxin II

Jackson, Katherine E., Spielmann, Tobias, Hanssen, Eric, Adisa, Akinola, Separovic, Frances, Dixon, Matthew W. A., Trenholme, Katharine R., Hawthorne, Paula L., Gardiner, Don L., Gilberger, Tim, Tille

Journal:

Biochemical Journal

Year:

2007

Language:

english

File:

PDF, 587 KB

english, 2007

47

Identification of Antimalarial Inhibitors Using Late-Stage Gametocytes in a Phenotypic Live/Dead Assay

Spicer, Timothy P., Gardiner, Donald L., Schoenen, Frank J., Roy, Sudeshna, Griffin, Patrick R., Chase, Peter, Scampavia, Louis, Hodder, Peter, Trenholme, Katharine R.

Journal:

Year:

2018

Language:

english

File:

PDF, 898 KB

english, 2018

48

Anti-Giardia drug discovery: Current status and gut feelings

Riches, Andrew, Hart, Christopher, Trenholme, Katharine, Skinner-Adams, Tina S.

Journal:

Journal of Medicinal Chemistry

Year:

2020

File:

PDF, 1.49 MB

2020